The Simons Foundation in New York City is seeking a Bioinformatics/Senior Bioinformatics Engineer (depends on experience) to develop and support whole exome and genome sequence data analysis pipelines in both research and operational modalities. This position will report to the Director of Data and Analytics in the informatics group and will work with other engineers and analysts in the informatics group, as well as with clinical and basic research teams at the foundation.
Design, develop and operate computational pipelines for next-generation sequencing data
Work on both large-scale projects and small custom tasks that span a wide variety of analysis problems
Develop new and/or improve upon existing algorithms for variant detection (SNPs and indels) and structural variant detection (CNVs, inversions and translocations) for clinical research purposes
Develop and maintain a knowledge base of variants and annotations discovered in processing of samples
Master’s degree or higher in bioinformatics, computational sciences or related field.
Over 3+ years’ work experience in research-and-development setting in bioinformatics
Experience with next-generation sequencing data
Experience in Linux/Unix cluster environment
Advanced programming skills in Python
Strong background in algorithm development, statistical methods, machine learning and distributed computing.
Extensive knowledge of computational genomics and experience with high-throughput data analysis
Outstanding personal initiative and the ability to work effectively as part of a team
Excellent verbal and written communication skills
Familiarity with C++, Perl, Matlab and R is desirable.
Familiarity with databases — relational and noSQL — cloud computing and web services is desirable.
The Simons Foundation’s Diversity Commitment
Many of the greatest ideas and discoveries come from a diverse mix of minds, backgrounds and experiences, and we are committed to cultivating an inclusive work environment. The Simons Foundation provides equal opportunities to all employees and applicants for employment without regard to race, religion, color, age, sex, national origin, sexual orientation, gender identity, genetic disposition, neurodiversity, disability, veteran status or any other protected category under federal, state and local law.
About Simons Foundation
The Simons Foundation is a private foundation established in 1994 in New York City by Jim and Marilyn Simons. With an annual grants and programs budget of $300 million, the foundation’s mission is to advance the frontiers of research in mathematics and the basic sciences.
The foundation pursues its mission through its grant-making division, comprising programs in Mathematics & Physical Sciences, Life Sciences, Education & Outreach and autism research, and through its internal research division, the Flatiron Institute.
The Mathematics & Physical Sciences program supports work in mathematics, theoretical computer science and theoretical physics. The Life Sciences program works to advance basic research in life sciences, with, among other efforts, large grant programs in ocean ecology and in the origins of life.
The Simons Foundation Autism Research Initiative (SFARI) is a campaign that aims to improve the understanding, diagnosis and treatment of autism by funding innovative research of the highest quality and relevance. SFARI also supports the editorially independent autism research news site Spectrum.
In 2016, the foundation launched the Flatiron Institute (FI), a multi...disciplinary institute whose mission is to advance scientific research through computational methods, including data analysis, modeling and simulation. The FI hosts scientists and collaborating expert programmers who work to create, deploy and support new state-of-the-art computational methods.
Education & Outreach supports and promotes scientific literacy in society generally. Specifically, the program supports the nonprofit Math for America and the independent science news site Quanta Magazine. This program’s Science Sandbox initiative seeks to unlock scientific thinking in all people, so that science becomes a more integral part of culture.